Ferroptosis as a promising therapeutic strategy for melanoma

Malignant melanoma (MM) is the most common and deadliest type of skin cancer associated with high mortality rates across all races ethnicities. Although present treatment options combined surgery provide short-term clinical benefit in patients early diagnosis non-metastatic MM significantly increases probability survival, no efficacious treatments are available for MM. The etiology pathogenesis complex. Acquired drug resistance a pool prognosis advanced-stage Thus, these require new therapeutic strategies to improve their response prognosis. Multiple studies have revealed that ferroptosis, non-apoptotic form regulated cell death (RCD) characterized by iron dependant lipid peroxidation, can prevent development Recent indicated targeting ferroptosis promising strategy This review article summarizes core mechanisms underlying cells its potential role as target We emphasize emerging types small molecules inducing pathways boosting antitumor activity BRAFi immunotherapy uncover beneficial effects treat also summarize application nanosensitizer-mediated unique dynamic ferroptosis-based nanodrug suggests pharmacological induction may be